Dermot Mulroney (1963 - )
- Young Guns (1988) [Dirty Steve Stephens]: Shot to death, along with Casey Siemaszko, in a shoot-out against the army and Jack Palance's henchmen.
- Longtime Companion (1989) [John]: Dies from complications of AIDS.
- Bad Girls (1994) [Josh McCoy]: Shot in the back by James Russo, after James pretends to release Dermot and lets him walk back towards Madeleine Stowe.
- There Goes My Baby (1994) [Pirate]: Killed in action in Vietnam on the Mekong Delta (off-screen). His death is revealed at the end of the film.
- Copycat (1995) [Rueben Goetz]: Shot in the back by Stuart W. Yee after Stuart grabs a police officer's gun during a hostage situation in the police station, as Holly Hunter looks on in shock.
- Kansas City (1996) [Johnny O'Hara]: Fatally stabbed (off-screen) by Harry Belafonte's thugs; he dies after staggering through the doorway and collapsing into Jennifer Jason Leigh's arms.
- Goodbye Lover (1998) [Jake Dunmore]: Killed in a motorcycle crash/explosion (along with Mary-Louise Parker) when Patricia Arquette forces their motorcycle off of a cliff at the end of a chase.
- Undertow (2004) [John Munn]: Throat slit by his brother (Josh Lucas) at the end of a fight; his body is shown again afterwards when his sons (Devon Alan and Jamie Bell) discover him.
- The Grey (2011) [Jerome Talget]: Fatally injured when the tether breaks as he's crossing the ravine, causing him to fall and slam into a tree; he is then mauled by wolves as he lies on the ground.
- Stoker (2013) [Richard Stoker]: Bludgeoned to death with a rock by his brother (Matthew Goode) who then stages the scene to look like a car accident.
- Careful What You Wish For (2015) [Elliott Harper]: Killed (off-screen) by his daughter (Isabel Lucas).
- Sleepless (2017) [Stanley Rubino]: Shot by David Harbour along with Michelle Monaghan (who survives her injuries).
- The Heart of Justice (1992 TV) [Elliot Burgess]: Commits suicide by shooting himself in the mouth after shooting Dennis Hopper in street.
- The Memory Keeper's Daughter (2008 TV) [Dr. David Henry]: Dies of a brain aneurysm while attempting to fix Gretchen Mol's sink.
- American Horror Story: Cult: Holes (2017) [Bob Thompson]: Stabbed in the head with a hatchet by Adina Porter as Evan Peters, Colton Haynes, Billy Eichner, Chaz Bono, Billie Lourd, Alison Pill and James Morosini look on.
- Brother of Kieran Mulroney.
- Ex-Mr. Catherine Keener.