James Spader (1960 - )
- The New Kids (1985) [Eddie Dutra]: Burned to death with a makeshift flamethrower from a lit gas nozzle by Shannon Presby at the end of a struggle.
- Jack’s Back (1988) [John/Rick Wesford]: Playing a dual role as twin brothers; 'John' is killed by the Jack the Ripper copycat.
- Stargate (1994) [Dr. Daniel Jackson]: Shot by a blast from Djimon Hounsou's staff; he is later brought back to life by Jaye Davidson's powers.
- Wolf (1994) [Stewart Swinton]: Shot repeatedly by Michelle Pfeiffer, causing him to fall into a pool while James is trying to kill Jack Nicholson with a hedge trimmer (with his body changing back into his human form as he dies).
- 2 Days in the Valley (1996) [Lee Woods]: Shot in the chest by Paul Mazursky as James is about to shoot Danny Aiello.
- The Homesman (2014) [Aloysius Duffy]: Burned alive when Tommy Lee Jones sets his house on fire; he dies shortly after jumping out the second floor window while engulfed in flames.
- Avengers: Age of Ultron (2015) [Ultron]: Playing a sentient A.I., he is killed when Paul Bettany destroys the final robot carrying his programming, after having previously been prevented from escaping into the internet. (James portrays this role through motion capture; his likeness is entirely CGI.)
- A Killer in the Family (1983) [Donny Tison]: Shot to death by police after crashing through a roadblock.